pI: 8.894 |
Length (AA): 469 |
MW (Da): 53875 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 4 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
1 | 277 | 1zar (A) | 17 | 266 | 22.00 | 0.000033 | 1 | 0.686218 | 0.38 |
32 | 278 | 1zth (A) | 6 | 244 | 38.00 | 0 | 1 | 0.942252 | -0.62 |
61 | 334 | 4otp (A) | 163 | 430 | 49.00 | 0 | 1 | 0.889822 | 0.38 |
339 | 450 | 3k3c (A) | 15 | 143 | 31.00 | 0.85 | 0.64 | 0.452406 | 0.04 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_127476)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT2G24990 | serine/threonine-protein kinase Rio1 |
Arabidopsis thaliana | AT5G37350 | Serine/threonine-protein kinase Rio1 |
Babesia bovis | BBOV_IV008960 | serine/threonine protein kinase, putative |
Brugia malayi | Bm1_49315 | RIO1 family protein |
Candida albicans | CaO19.2320 | chromosome condensation/seggregation |
Candida albicans | CaO19.9856 | chromosome condensation/seggregation |
Caenorhabditis elegans | CELE_M01B12.5 | Protein RIOK-1, isoform B |
Cryptosporidium hominis | Chro.50179 | extragenic suppressor of the bimD6 mutation-related |
Cryptosporidium parvum | cgd5_2000 | protein with RIO domain within N-terminal region |
Dictyostelium discoideum | DDB_G0280431 | RIO family protein kinase |
Drosophila melanogaster | Dmel_CG11660 | RIO kinase 1 |
Echinococcus granulosus | EgrG_000433900 | serine:threonine protein kinase RIO1 |
Entamoeba histolytica | EHI_050990 | RIO1 family protein |
Echinococcus multilocularis | EmuJ_000433900 | serine:threonine protein kinase RIO1 |
Giardia lamblia | GL50803_17449 | RIO1-like protein |
Homo sapiens | ENSG00000124784 | RIO kinase 1 |
Leishmania braziliensis | LbrM.29.0250 | hypothetical protein, conserved |
Leishmania donovani | LdBPK_290250.1 | RIO1 family, putative |
Leishmania infantum | LinJ.29.0250 | hypothetical protein, conserved |
Leishmania major | LmjF.29.0240 | hypothetical protein, conserved |
Leishmania mexicana | LmxM.08_29.0240 | hypothetical protein, conserved |
Loa Loa (eye worm) | LOAG_00084 | atypical/RIO/RIO1 protein kinase |
Mus musculus | ENSMUSG00000021428 | RIO kinase 1 (yeast) |
Neospora caninum | NCLIV_011910 | Testis cDNA clone: QtsA-11516, similar to human RIO kinase 3 (yeast) (RIOK3), transcript variant 1,, related |
Oryza sativa | 4342459 | Os07g0162300 |
Plasmodium berghei | PBANKA_1445600 | serine/threonine protein kinase RIO1, putative |
Plasmodium falciparum | PF3D7_1230900 | serine/threonine protein kinase RIO1, putative |
Plasmodium knowlesi | PKNH_1450300 | serine/threonine protein kinase RIO1, putative |
Plasmodium vivax | PVX_124185 | serine/threonine protein kinase RIO1, putative |
Plasmodium yoelii | PY01572 | extragenic suppressor of the bimD6 mutation-related |
Saccharomyces cerevisiae | YOR119C | Rio1p |
Schistosoma japonicum | Sjp_0090620 | ko:K07178 RIO kinase 1, putative |
Schistosoma japonicum | Sjp_0090610 | ko:K07178 RIO kinase 1, putative |
Schistosoma mansoni | Smp_022140 | serine/threonine-protein kinase rio1 (rio kinase 1) |
Schmidtea mediterranea | mk4.001217.01 | Serine/threonine-protein kinase RIO1 |
Trypanosoma brucei gambiense | Tbg972.3.6100 | hypothetical protein, conserved |
Trypanosoma brucei | Tb927.3.5400 | serine/threonine protein kinase RIO1, putative |
Trypanosoma congolense | TcIL3000_3_3340 | RIO1 family, putative |
Trypanosoma cruzi | TcCLB.508409.150 | serine/threonine protein kinase RIO1, putative |
Toxoplasma gondii | TGME49_210830 | RIO1 family protein |
Theileria parva | TP01_0880 | hypothetical protein |
Trichomonas vaginalis | TVAG_283340 | RIO family atypical protein kinase |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.3.5400 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.3.5400 | Trypanosoma brucei | significant gain of fitness in bloodstream forms (6 days) | alsford |
Tb927.3.5400 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb927.3.5400 | Trypanosoma brucei | significant gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_M01B12.5 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_M01B12.5 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_M01B12.5 | Caenorhabditis elegans | larval lethal | wormbase |
CELE_M01B12.5 | Caenorhabditis elegans | slow growth | wormbase |
CELE_M01B12.5 | Caenorhabditis elegans | sterile | wormbase |
YOR119C | Saccharomyces cerevisiae | inviable | yeastgenome |
PBANKA_1445600 | Plasmodium berghei | Slow | plasmo |
TGME49_210830 | Toxoplasma gondii | Probably essential | sidik |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Homo sapiens | RIO kinase 1 | Compounds | References |